职称/职务：

讲师

学历/学位：

研究生/博士

毕业院校：

韩国庆尚国立大学

联系电话：

15704460912

办公地点：

生物技术专业实验室401-B

电子邮箱：

xu218428@163.com

个人简介（依次介绍学习/进修经历、个人的教科研方向、荣誉称号、教科研成果等）

2014年毕业于吉林农业大学，获动物科学专业学士学位；

2017年毕业于韩国庆尚国立大学，获应用生命科学专业硕士学位；

2021年毕业于韩国庆尚国立大学，获应用生命科学专业博士学位。

主要从事动物生物技术方面的教学科研工作，在国内、外刊物上发表论文10余篇。

主讲课程

动物基因工程实验；家畜生态学

主要研究领域

动物胚胎的体外生产：

1. 未成熟卵的体外成熟，体外受精，以及胚胎的体外培养;

2. 通过对相应抗体的研究，体外控制胚胎的性别

3. 卵胞浆内单精子显微注射技术(ICSI)

4. 卵子，精子 以及胚胎的冻融技术

体细胞克隆技术：

1. 从卵母细胞成熟、供体细胞制备、融合、卵母细胞激活和胚胎培养等方面研究克隆技术

2. 改良体细胞的克隆技术，提高克隆的成功率已经克隆胚胎的发育潜能

代表性成果

l代表论文：

1. Lianguang Xu*, Seok-Hwan Song, Muhammad Idrees, Ayman Mesalam, Myeong-Don Joo, Tabinda Sidrat, Yiran Wei, Kyeong-Lim Lee, Wenfa Lu, Il-Keun Kong. Effects of Donor Cell Types on the Development of Bovine Embryos Using Cytoplasm Injection Cloning Technology. Int J Mol Sci. 2021 May 29;22(11):5841. (* Equally contributed) (一作，SCIE IF: 5.923 中科院2区).

2. Lianguang Xu*, Muhammad Idrees, Myeong-Don Joo, Tabinda Sidrat , Yiran Wei, Seok-Hwan Song, Kyeong-Lim Lee, Il-Keun Kong. Constitutive Expression of TERT Enhances β-Klotho Expression and Improves Age-Related Deterioration in Early Bovine Embryos. Int J Mol Sci. 2021 May 18;22(10):5327. (* Equally contributed) (一作，SCIE IF: 5.923 中科院2区).

3. Lianguang Xu*, Ayman Mesalam*, Kyeong-Lim Lee, Seok-Hwan Song, Imran Khan, M.M.R. Chowdhury, Wenfa Lv, and Il-Keun Kong. Improves the In Vitro Developmental Competence and Reprogramming Efficiency of Cloned Bovine Embryos by Additional Complimentary Cytoplasm. Cell Reprogram. 2019 Feb;21(1):51-60. doi: 10.1089/cell.2018.0050. (* Equally contributed) (一作，SCIE IF: 1.702 中科院4区).

4. Seok-Hwan Song*, Kyeong-Lim Lee*, Lianguang Xu*, Myeong-Don Joo, Ji-Yoon Hwang, Seon-Hwa Oh, Il-Keun Kong. Production of cloned cats using additional complimentary cytoplasm. Anim Reprod Sci. 2019 Sep; 208:106125. (* Equally contributed) (共同一作，SCI IF: 1.66 中科院3区).

5. Seok-Hwan Song*, Seon-Hwa Oh*, Lianguang Xu*, Kyeong-Lim Lee, Ji-Yoon Hwang, Myeong-Don Joo Joo, Il-Keun Kong. Effect of Additional Cytoplasm of Cloned Embryo on In Vitro Developmental Competence and Reprogramming Efficiency in Mice. Cell Reprogram. 2020 Aug 24. (* Equally contributed) (共同一作，SCIE IF: 1.987 中科院4区).

6. Yu-GuoYuan*, Lianguang Xu*, Shimin Zhang, Ayman Mesalam, Kyeong-Lim Lee, Hongyu Liu, Myeong-Don Joo, Muhammad Idrees, Il-Keun Kong. Polydatin and I-CBP112 protects early bovine embryo against nicotinamide-induced mitochondrial dysfunction. Theriogenology. 2019 Aug;134:1-10. (* Equally contributed) (共同一作，SCI IF: 2.094 中科院2区).

7. M.M.R. Chowdhury*, Lianguang Xu*, Rami Kong*, Bun-Young Park, Ayman Mesalam, Myeong-Don Joo, Fahmida Afrin, Jong-In Jin, Hyun-Tae Lim, Il-Keun Kong. In vitro production of sex preselected cattle embryos using a monoclonal antibody raised against bull sperm epitopes. Anim Reprod Sci. 2018 Nov 16. pii: S0378-4320(18)30787-5. (* Equally contributed) (共同一作，SCI IF: 1.66 中科院3区).

8. Imran Khan, Kyeong-lim Lee, Lianguang Xu, Ayman Mesalam, MMR Chowdhury, Myeong-Don Joo, Ihsan-ul-Haq, Bushra Mirza, and Il-Keun Kong. Improvement of in vitro-produced bovine embryo treated with coagulansin-A under heat-stressed condition. Reproduction. 2017 153(4):421-431 (SCI IF: 3.906 中科院3区).

9. M.M.R. Chowdhury, Ayman Mesalam, Imran Khan, Myeongdon Joo, Kyeong-Lim Lee, Lianguang Xu, Fanmida Afrin, Il-Keun Kong. Improved Developmental Competence in Embryos Treated with Lycopene during In Vitro Culture. Mol Reprod Dev. 2017 Dec 8 (SCI IF: 3.113 中科院3区).

10. M.M.R. Chowdhury, Byung-Hyun Choi, Imran Khan, Kyeong-Lim Lee, Ayman Mesalam, Seok-Hwan Song, Lianguang Xu, Myeong-Don Joo, Fahmida Afrin, Il-Keun Kong. Supplementation of lycopene in maturation media improves bovine embryo quality in vitro. Theriogenology. 2017 Nov;103:173-184 (SCI IF: 2.74 中科院2区).

11. Muhammad Idrees, Lianguang Xu, Seok-Hwan Song, Myeong-Don Joo, Kyeong-Lim Lee, Tahir Muhammad, Marwa El Sheikh, Tabinda Sidrat and Il-Keun Kong. PTPN11 (SHP2) Is Indispensable for Growth Factors and Cytokine Signal Transduction During Bovine Oocyte Maturation and Blastocyst Development. Cells. 2019 Oct 18;8(10). pii: E1272. doi: 10.3390/cells8101272 (SCIE IF: 6.60 中科院2区).

12. Muhammad Idrees, Lianguang Xu, Marwa El Sheikh, Tabinda Sidrat, Seok-Hwan Song, Myeong-Don Joo, Kyeong-Lim Lee and Il-Keun Kong. The PPARδ Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos. Int J Mol Sci. 2019 Dec 2;20(23). pii: E6066 (SCIE IF: 5.923 中科院2区).

13. Shimin Zhang, Mesalam Ayman, Kyeong-Lim Lee, Seok-Hwan Song, Lianguang Xu, Khan Imran, Yuguo Yuan, Wenfa LV, Il-Keun Kong. Effect of Predator Stress on the Reproductive Performance of Female Mice After Nonsurgical Embryo Transfer. J Am Assoc Lab Anim Sci. 2019 May 1;58(3):304-310 (SCIE IF: 0.988 中科院4区).

14. Tabinda Sidrat, Rami Kong, Abdul Aziz Khan, Muhammad Idrees, Lianguang Xu, Marwa El Sheikh, Myeong-Don Joo, Kyeong-Lim Lee and Il-Keun Kong. Difference in Developmental Kinetics of Y Specific Monoclonal Antibody Sorted Male and Female In Vitro Produced Bovine Embryos. Int J Mol Sci. 2020 Jan; 21(1): 244 (SCIE IF: 5.923 中科院2区).

15. Tabinda Sidrat, Abdul Aziz Khan, Muhammad Idrees, Myeong-Don Joo, Lianguang Xu, Kyeong-Lim Lee and Il-Keun Kong. Role of Wnt Signaling During In-Vitro Bovine Blastocyst Development and Maturation in Synergism with PPARδ Signaling. Cells. 2020 Apr; 9(4): 923 (SCIE IF: 6.60 中科院2区).

16. Shimin Zhang, Ayman Mesalam, Myeong-Dong Joo, Kyeong-Lim Lee, Ji-Yoon Hwang, Lianguang Xu, Seok-Hwan Song, Phil-Ok Koh, Yu-Guo Yuan, Wenfa Lv, Il-Keun Kong. Matrix metalloproteinases improves trophoblast invasion and pregnancy potential in mice. Theriogenology. 2020 Jul 15;151:144-150 (SCI IF: 2.74 中科院2区).

17. Hongyu Liu, Ayman Mesalam, Myeong-Don Joo, Shimin Zhang, Lianguang Xu, Jun Wang, Kyeong-Lim Lee, Seok-Hwan Song, Yu-Guo Yuan, Wenfa Lu, Il-Keun Kong. Fibronectin protected bovine preantral follicles from the deleterious effects of Kisspeptin. Theriogenology. 2021 Feb;161:301-312 (SCI IF: 2.74 中科院2区).

18. Yu-Guo Yuan , Ayman Mesalam , Seok-Hwan Song, Kyeong-Lim Lee, Lianguang Xu, Myeong-Don Joo, Il-Keun Kong. Effect of nicotinamide supplementation in in vitro fertilization medium on bovine embryo development. Mol Reprod Dev. 2020 Oct;87(10):1070-1081. doi: 10.1002/mrd.23417. Epub 2020 Sep 4. (SCI IF: 2.609 中科院3区).

19. Tabinda Sidrat, Abdul Aziz Khan, Myeon-Don Joo, Yiran Wei, Kyeong-Lim Lee, Lianguang Xu, Il-Keun Kong. Bovine Oviduct Epithelial Cell-Derived Culture Media and Exosomes Improve Mitochondrial Health by Restoring Metabolic Flux during Pre-Implantation Development. Int J Mol Sci. 2020 Oct 14;21(20):7589. doi: 10.3390/ijms21207589. (SCIE IF: 5.923 中科院2区)